VIRAL METAGENOMIC INVESTIGATION OF TWO CARIBBEAN ECHINODERMS, DIADEMA ANTILLARUM (ECHINOIDEA) AND HOLOTHURIA FLORIDANA (HOLOTHURIA)

Viral metagenomic investigation of two Caribbean echinoderms, Diadema antillarum (Echinoidea) and Holothuria floridana (Holothuria)

Background Echinoderms play crucial roles in coral reef ecosystems, where they are significant detritivores and herbivores.The phylum is widely known for its boom and bust cycles, driven by food availability, predation pressure and mass mortalities.Hence, surveillance of potential pathogens and associates of grossly normal specimens is important to

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Disruption of PHF21A causes syndromic intellectual disability with craniofacial anomalies, epilepsy, hypotonia, and neurobehavioral problems including autism

Abstract Background PHF21A has been associated with intellectual disability and craniofacial anomalies based on its deletion in the Potocki-Shaffer syndrome region at 11p11.2 and its disruption in three patients with balanced translocations.In addition, three patients with de novo truncating mutations in PHF21A were reported recently.Here, we analy

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